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    There are so many questions from SME businesses that are looking for debt finance of some sort or another. Valuable time is wasted by SME stakeholders trying to source the right deal from the right people at the right price for the right reason. It can be a mi
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    nefield which may not be as desperate as leading to a company downfall but lack of funds not available within a reasonable timeframe can spell the beginning of missed opportunities, months of struggle and eventually an insolvency disaster waiting to happen.

    <
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    >What is the finance for?

    Be clear on what you want your finance for. If you are looking at:

    * Working capital
    * Expansion - skills, diversification or perhaps acquisition
    * Development of ideas
    * For use in the actual product
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    or service
    * Proving the market
    * Proving the product

    Or something else in this vein then go for it.

    If you are looking for funds to:
    * Cover losses
    * Repay your debts
    * Paying your salary

    Then gen
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    rally speaking, forget it!

    Have you seen Dragon's Den on BBC2? What happens when the entrepreneur divulges the fact that the funding they are looking for is to go on wages? Yep, even if you've not seen the show you can probably guess. The entrepreneur walks a
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    way empty-handed. If you are just trying to repay debt then perhaps it's time to talk to the professionals and get some sound advice.

    Types of finance (UK)

    Consider all the funding options available. Look around your local area, talk to the chambers o
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    commerce, find out the local investment trusts. Ultimately, make sure you pitch to the right type of funder to suit your borrowing requirement.

    As a rough guide, consider:
    - Debt finance / Small firms loan guarantee (SMFLG) (?5k+)
    - Frien
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    ds and family (Up to ?80k)
    - Business angels (Typically ?50k up to ?500k)
    - Specialist funds / sometimes wealthy business angels in a niche market (Up to ?2M)
    - Venture capital firms (?1.5M+)

    Outside or in conjunction with the abov
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    you may also do well to consider asset finance companies (assuming you have assets in your business) and also invoice discounting / factoring (assuming you have a debtor book and robust contracts terms and conditions of business).

    Some key issues

    The
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    funding companies that you approach will be looking at other issues surrounding your business. To be a little crude, they'll want you to 'show them the colour of your business underwear'. So what will they want to know?

    - Financials - How do the numbers rela
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    e to your plan? - Are the numbers consistent? - Can you confidently recall the key numbers and understand how they relate to your business?

    - The management team - The right blend of skills to see the goal through? - Concentrically focussed? - The right produ
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    ct with the wrong team is generally less attractive than the wrong product with the right team! - Ability to deliver in spite of setbacks

    - Product / Service - Do you have a unique selling point (USP) that makes you stand out from the competition? - Have you
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    rotected your interests in the product or service?

    - The marketplace - How big is your market? - Who's your competition? Tip: Never say 'we don't have competition'. You may have a USP but there is always competition even if it's an alternative solution to you
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    r offering. Make sure you come across as knowledgeable about how you fare against the competition. - How will you get access to your market?

    Really understand these key issues. The funding companies are checking you out as much as the numbers relating to the
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    eal.

    Don't ask for too little or too much

    If you really understand your business to the level that a funding company would like then you would get the request for money correct the first time you ask. It's embarrassing if you get the figures wrong.

    <
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    b>Write out a cashflow forecast for your proposition.

    Remember that the greatest gap between revenue and overhead costs may not be month 1 or 2, it may be 8 months down the line.

    A typical cycle for raising finance may take 2 to 18 months. If you run ou
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    of cash in month 9 and you're 5 months from the next injection of funding then you may not survive the year. The extra costs associated with filling a cashflow gap may also squeeze your margins to the point you operate at a loss.

    Too much funding is equally
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    embarrassing. You have to pay the funding company for that extra cash in the business and potentially at a later date request more funding if say you hit upon a needed expansion plan. What will the perception be of a company asking for funding who were wildly
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    ut on figures the last time around?

    Summary

    There are a number of options available in the UK for business funding.

    Asking for the right amount of funding, for the right reason with the right lending source will save you time and costs. Make sure you
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    do the work and demonstrate your ability to run and manage your business.

    As a footnote, if you still cannot get funding and are faced with insolvency / personal debts and you would like some help and advice then do get professional help as early as possible


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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